DSMLink runs under Vista about as well as anything else. That is, you'll probably find some quirks to the experience and you'll probably have to do a few things a little differently at first. But, eventually, it'll all work fine.

Installation works best if you can install as the administrator. Failing that, if you copy the install executable to your harddrive somewhere and rename it setup.exe, it should work as well.

Vista prevents programs from writing to the real Program Files directory, where DSMLink writes logs by default, by instead writing to a shadow directory: c:\Users\[username]\AppData\Local\VirtualStore\Program Files\Dsmlink\runs. You'll find the physical files you capture there. We suggest explicitly writing logs to your own directory under your user directory. You can use the small “…” button next to the filename text area on the main screen for this or you can do a File→Save As and simply navigate to the new directory where you want datalogs saved from then on.

Also, the Java virtual machine is is not compatible with the Vista Aero (CPU hog) interface. Vista disables the Aero interface while DSMLink is running.